DNA methylation and histone modification in onion chromosomes
نویسندگان
چکیده
منابع مشابه
The Impression of Histone Modification and DNA Methylation in Gastric Cancer Development: Molecular Mechanism Approach
The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories including nucleosome remodeling and RNA mediated targeting have been strongly investigated recently .In this way , beside the notable importance of DNA methylation ,the histone modifications are the most important issues in the tumorogenesis and cancer progression. Moreover...
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the epigenetic alterations like histone modifications , dna methylation and others remarkable categories including nucleosome remodeling and rna mediated targeting have been strongly investigated recently .in this way , beside the notable importance of dna methylation ,the histone modifications are the most important issues in the tumorogenesis and cancer progression. moreover, the fluctuati...
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The JmjC domain-containing histone demethylases can remove histone lysine methylation and thereby regulate gene expression. The JmjC domain uses iron Fe(II) and α-ketoglutarate (αKG) as cofactors in an oxidative demethylation reaction via hydroxymethyl lysine. We hypothesize that reactive oxygen species will oxidize Fe(II) to Fe(III), thereby attenuating the activity of JmjC domain-containing h...
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Genes constitute only a small proportion of the mammalian genome, the majority of which is composed of non-genic repetitive elements including interspersed repeats and satellites. A unique feature of the mammalian genome is that there are numerous tissue-dependent, differentially methylated regions (T-DMRs) in the non-repetitive sequences, which include genes and their regulatory elements. The ...
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Carcinogenesis as well as cancer progression result from genetic and epigenetic changes of the genome that leads to dysregulation of transcriptional activity of genes. Epigenetic mechanisms in cancer cells comprise (i) post-translation histone modification (i.e., deacetylation and methylation); (ii) DNA global hypomethylation; (iii) promoter hypermethylation of tumour suppressor genes and genes...
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ژورنال
عنوان ژورنال: Genes & Genetic Systems
سال: 2010
ISSN: 1341-7568,1880-5779
DOI: 10.1266/ggs.85.377